Set in the aftermath of the events that caused the entire world to forget Peter Parker's civilian identity, the young hero finds himself navigating a completely isolated life in the slums of New York City, without the support of his former friends and allies. As he tries to start over and redefine his role as the city's protector, Peter must contend with new threats emerging from the criminal underworld while also grappling with the weight of the responsibilities of being Spider-Man, as every connection to the past seems to have been dissolved forever.